The Effects of Pistacia Vera Seed Oil on Anxiety and Depressive-Like Behaviors in Rats with Polycystic Ovary Syndrome

Document Type: Original Article

Authors

1 Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

2 Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Department of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

3 Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Department of Internal Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

4 Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

10.22123/phj.2019.170505.1025

Abstract

 
 

Keywords


 

 

The Effects of Pistacia Vera Seed Oil on Anxiety and

Depressive-Like Behaviors in Rats with Polycystic Ovary Syndrome

Mohammadreza Mohammadi-Nasab (MSc)1,2,3, Iman Fatemi (PhD)4, Mohammad Pak-Hashemi (MSc)1,2,3, Mitra Abbasi-Fard (MD)5,6, Mahsa Hassanipour (PhD)1,2*

 1 Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences,

Rafsanjan University of Medical Sciences, Rafsanjan, Iran

2 Department of Physiology and Pharmacology, School of Medicine,

Rafsanjan University of Medical Sciences, Rafsanjan, Iran

3 Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

4 Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

5 Molecular Medicine Research Center, Research Institute of Basic Medical Sciences,

Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

6 Department of Internal Medicine, Ali-Ebn Abitaleb Hospital,

Rafsanjan University of Medical Sciences, Rafsanjan, Iran

 

Received: 6 Feb. 2019   Accepted: 6 Mar. 2019

 

Abstract

 

Introduction: Polycystic ovary syndrome (PCOS) is associated with many complications. Neurobehavioral deficits are reported in women with PCOS. Patients with PCOS show a high risk for affective disorders, which impair the quality of life. Finding a safe herbal medicine for these complications is valuable. Pistacia vera plays a beneficial role in central nervous disorders. The current study is designed to evaluate the effects of Pistacia vera oil on depression and anxiety-like behaviors in female rats with letrozole-induced PCOS.

 

Methods: Letrozole (1 mg/kg) was used orally in order to induce PCOS. Pistachio oil (1 and 4 ml/kg) was administered with letrozole. After 21 days, elevated plus-maze test, forced swimming test (FST), and open field tests were performed.

 

Results: The data showed that the PCOS condition led to immobility time enhancement in the FST (P<0.001). PCOS animals significantly exhibited anxiety-like behaviors (P<0.05). Treatment with pistachio oil with doses of 1 and 4 ml/kg completely blocked the deleterious effects of PCOS on behavioral parameters.

 

Conclusion: Pistacia vera oil could alleviate depression and anxiety in rats with PCOS.

 

 

 


 

Please cite this article as follows:

 Mohammadi-Nasab M, Fatemi I, Pak-Hashemi M, Abbasi-Fard M, Hassanipour M. The effects of pistacia vera seed oil on anxiety and depressive-like behaviors in rats with polycystic ovary syndrome. Pistachio and Health Journal. 2019; 2 (1): 1-9.