Document Type : Original Article
Authors
1 Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2 Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Department of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3 Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Department of Internal Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4 Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Abstract
Keywords
The Effects of Pistacia Vera Seed Oil on Anxiety and
Depressive-Like Behaviors in Rats with Polycystic Ovary Syndrome
Mohammadreza Mohammadi-Nasab (MSc)1,2,3, Iman Fatemi (PhD)4, Mohammad Pak-Hashemi (MSc)1,2,3, Mitra Abbasi-Fard (MD)5,6, Mahsa Hassanipour (PhD)1,2*
1 Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences,
Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2 Department of Physiology and Pharmacology, School of Medicine,
Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3 Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4 Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
5 Molecular Medicine Research Center, Research Institute of Basic Medical Sciences,
Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
6 Department of Internal Medicine, Ali-Ebn Abitaleb Hospital,
Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Received: 6 Feb. 2019 Accepted: 6 Mar. 2019
Abstract
Introduction: Polycystic ovary syndrome (PCOS) is associated with many complications. Neurobehavioral deficits are reported in women with PCOS. Patients with PCOS show a high risk for affective disorders, which impair the quality of life. Finding a safe herbal medicine for these complications is valuable. Pistacia vera plays a beneficial role in central nervous disorders. The current study is designed to evaluate the effects of Pistacia vera oil on depression and anxiety-like behaviors in female rats with letrozole-induced PCOS.
Methods: Letrozole (1 mg/kg) was used orally in order to induce PCOS. Pistachio oil (1 and 4 ml/kg) was administered with letrozole. After 21 days, elevated plus-maze test, forced swimming test (FST), and open field tests were performed.
Results: The data showed that the PCOS condition led to immobility time enhancement in the FST (P<0.001). PCOS animals significantly exhibited anxiety-like behaviors (P<0.05). Treatment with pistachio oil with doses of 1 and 4 ml/kg completely blocked the deleterious effects of PCOS on behavioral parameters.
Conclusion: Pistacia vera oil could alleviate depression and anxiety in rats with PCOS.
►Please cite this article as follows:
Mohammadi-Nasab M, Fatemi I, Pak-Hashemi M, Abbasi-Fard M, Hassanipour M. The effects of pistacia vera seed oil on anxiety and depressive-like behaviors in rats with polycystic ovary syndrome. Pistachio and Health Journal. 2019; 2 (1): 1-9.