Amelioration of Cisplatin-Induced Liver Toxicity Through Antioxidative Properties of Hydroalcoholic Extract of Pistachio Nuts in Mice

Document Type: Original Article

Authors

1 Physiology-Pharmacology Research Center, Rafsanjan University of Medical sciences

2 Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences

3 Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences.

10.22123/phj.2020.234540.1046

Keywords


 

Amelioration of Cisplatin-Induced Liver Toxicity Through Antioxidative

Properties of Hydroalcoholic Extract of Pistachio Nuts in Mice

 

Elham Hakimizadeh (PhD)1, Ayat Kaeidi (PhD)1,2, Jalal Hassanshahi (PhD)1,2, Ali Shamsizadeh (PhD)1.2, Mohammad Allahtavakoli (PhD)1,2, Mohammad-Reza Rahmani (PhD)1,2, Iman Fatemi (PhD)3*

 

1 Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences,

Rafsanjan University of Medical Sciences, Rafsanjan, Iran

 2 Department of Physiology and Pharmacology, School of Medicine,

 Rafsanjan University of Medical Sciences, Rafsanjan, Iran

 3 Research Center of Tropical and Infectious Diseases,

 Kerman University of Medical Sciences, Kerman, Iran

 

Received: 10.06.2020   Accepted: 24.08.2020

 

 Abstract

 

Introduction: Pistachio are known for their medicinal properties and have many pharmacological effects such as antioxidant activity. This study aimed to investigate the effects of hydroalcoholic pistachio extract (PE) in the pathogenesis of cisplatin (Cis)-induced liver toxicity.

 

Materials and Methods: In this experimental study, 35 male mice were assigned randomly into four groups. Liver toxicity was induced in mice by intraperitoneal injection of Cis (20 mg/kg/day on the first day of the experiment). PE (10 and 100 mg/kg; p.o) was administered on day 1 (1 h before cisplatin injection) and continued for three consecutive days. At the end of the experiment, blood samples were obtained to measure serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Moreover, the activities of catalase (CAT) and glutathione peroxidase (GPx) in the liver tissue were evaluated

 

Results: Cis increased the serum levels of AST, ALT, and ALP as well as decreasing the activities of CAT and GPx. Administration of PE at the dose of 10 mg/kg for four days showed a significant decline in the serum levels of AST and ALT. Treatment of Cis-treated mice with 100 mg/kg PE decreased the serum levels of AST, ALP, and ALT as well as increasing CAT and GPx activities in the hepatic tissue.

 

Conclusion: These findings demonstrate that PE could be an effective remedy for the prevention of cisplatin-induced liver dysfunction and oxidative damage in mice

 

 


 

 Please cite this article as follows:

Hakimizadeh E, Kaeidi A, Hassanshahi J, Shamsizadeh A, Allahtavakoli M, Rahmani MR, et al. Amelioration of cisplatin-induced liver toxicity through antioxidative properties of hydroalcoholic extract of pistachio nuts in mice. Pistachio and Health Journal. 2019; 2 (2): 34-41.