Document Type : Original Article
Subjects
Protective Effects of Pistachio Extract Against Diazinon: Mitigating Uterine Damage and Oxidative Stress
Arezoo Khoradmehr (MSc)1, Soheila Pourmasumi (PhD)2,3, Amir Rahnama (MD)4,5, Danial Saeidi (MD)6, Parvin Khalili (PhD)2,7, Armin khodaparast (MSc Student)8, Mehrnoosh Mehrabian (MD)9, Amirreza Shakoeizadeh (MD)6, Soudeh Khanamani Falahati-pour (PhD)10*
1 The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
2 Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3 Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4 Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5 Department of Pathology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
6 Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
7 Department of Epidemiology, School of Public Health, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
8 Department of Biological Science and Technology, Faculty of Nano and Bioscience and Technology, Persian Gulf University, Bushehr, Iran
9 Department of Community Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
10 Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Received: 09.02.2024 Accepted: 03.04.2024
Abstract
Background and Objectives: The widespread use of the organophosphate pesticide diazinon has raised concerns about its possible harmful effects on reproductive health. This study aimed to examine the protective effects of pistachio pericarp essential oil against uterine damage and oxidative stress caused by diazinon in mice.
Materials and Methods: Six groups were formed: control, corn oil vehicle, diazinon, diazinon with 5% pistachio extract, diazinon with 10% pistachio extract, and 10% pistachio extract alone. After 28 days of daily gavage treatments, uterine tissues were collected for histomorphometric analysis and assessment of oxidative stress markers like MDA and SOD.
Results: Diazinon significantly raised malondialdehyde (MDA) levels and lowered superoxide dismutase (SOD) activity compared to the control, indicating heightened oxidative stress. It also decreased endometrial thickness and uterine diameter, suggesting structural damage. Importantly, treatments with pistachio extract, especially at 10%, effectively alleviated these negative effects, reducing MDA levels, increasing SOD activity, and improving uterine tissue morphology. Conclusion: The results indicate that diazinon may impair fertility by causing oxidative stress and uterine tissue damage. Conversely, pistachio pericarp extract offers protective benefits, likely due to its antioxidant properties. This study underscores the potential of natural extracts to counteract the reproductive toxicity of pesticides.
Conclusion: The results indicate that diazinon may impair fertility by causing oxidative stress and uterine tissue damage. Conversely, pistachio pericarp extract offers protective benefits, likely due to its antioxidant properties. This study underscores the potential of natural extracts to counteract the reproductive toxicity of pesticides.
►Please cite this article as follows:
Khoradmehr A, Pourmasumi S, Rahnama A, Saeidi D, Khalili P, khodaparast A, Mehrabian M, Shakoeizadeh Amirreza, Falahati-pour SK. Protective Effects of Pistachio Extract Against Diazinon: Mitigating Uterine Damage and Oxidative Stress. Pistachio and Health Journal. 2024;7(1-2):15-26.
